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ApoE plays an essential role in protecting neurons from lipid peroxidation by shuttling oxidized fatty acids that accumulate during neuronal activity from neurons to astrocytes for storage in lipid droplets or use in energy via -oxidation [51]

Toxins 17:399

Inhibiting Drp1 can help balance mitophagy and improve mitochondrial abnormalities associated with ADOA

These combinations deserve to be further studied for possible clinical applications, particularly for inhaled formulations that would enable the high NALC concentration to be reached at the infection site in cases with pulmonary infections while minimizing systemic toxicity

Our study indicates the importance of IGF-1R in maintaining a balance between cell survival and apoptosis of GNE deficient cells that are of interest to be explored further for drug design in disorders associated with sialic acid deficiency