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When relief of pain from treatment with GnRH agonist supports continued therapy, the addition of add-back therapy reduces or eliminates GnRH agonist-induced bone mineral loss and provides symptomatic relief without reducing the efficacy of pain relief

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Analysis of the chemical composition of the extract using HPLC found that the active ingredient playing the main role was also cynaroside

A prospective cohort study covering Canada and the United States, involving 865 cardiac surgery patients, demonstrated that elevated postoperative urinary EGF levels significantly indicate a low risk of CKD onset or progression, whereas elevated urinary MCP-1 levels independently predicted long-term adverse CKD outcomes [238]