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If you inhale smoke from anything there will be carbon monoxide [CO] in the smoke, and that has a very high affinity for Haemoglobin, which is why a small %age of CO can kill

its protective effects against cardiovascular disease are unclear

Further reading: Vitamin B12 and Folic Acid The MTHFR Gene The critical stage in the folate cycle is the conversion of 5, 10-methylenetetrahydrofolate to 5-MTHF, which is then used in the methionine cycle

(10) Streeper RS, et al

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