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80 XuD.SuC.SongX.ShiQ.FuJ.HuL.et al (2015)

The yeast Saccharomyces cerevisiae contains two genes encoding glutaredoxins ( GRX1 and GRX2 ) that share extensive homology with glutaredoxins from bacterial and mammalian species (Luikenhuis et al ., 1997)

Although the value of serum MMP-9 as an independent monitoring and prognostic biomarker has been questioned by large-sample studies, highlighting the need for careful consideration of source specificity in its clinical application, the overall central role of MMPs as core biomarkers in disease progression and treatment prediction remains solid

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The regulatory pathway for biomarker approval adds additional complexity and delay to clinical implementation (Nisenblat et al., 2016)