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Manifestations of neurotoxicity were not examined in any of these studies

Dec 2002;26(12):1588-1595

Synthesis and thermodynamic and biophysical properties of tricyclo-DNA

It is not just inflammation that is involved in the development of neurodegeneration, but also several factors that interact amongst themselves and that include mitochondrial damage, which is closely related to oxidative stress 8,9

GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)