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Combination of metabolic inhibitors with immune checkpoint blockade: Pairing PD-1/PD-L1 or CTLA-4 inhibitors with agents targeting cancer cell metabolism (glycolysis, glutaminolysis) to simultaneously reduce metabolic competition and enhance checkpoint inhibitor efficacy

These can occur with the aqueous solution or the crystalloid suspension form, employed to confer them a longer-lasting effect.2,3 Skin hypopigmentation has been reported to occur in 1.3%6% of patients who underwent local corticosteroid injection.2,4 It generally occurs 14 months after injection and takes 630 months to resolve.1 Subcutaneous fat atrophy after local injection of corticosteroids has an estimated incidence that varies from 1.5 to 40%.510 In most cases, these two complications are self limited but may last 6 to 24 months.11 Rare cases have been described where no spontaneous improvement occurs, in which surgical treatment should be considered

2020, 10, e00114 10.1016/j.mec.2019.e00114

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The P2X7 receptor is involved in inflammation triggered by SiO 2 and TiO 2 UFPs by increasing IL-1 secretion, likely through the inflammasome pathway 91