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6,15 In children with frequent attacks (more than 1 or 2 per month), repeated hospitalizations, or poor response to abortive treatment, prophylactic drug treatment may be initiated ( TABLE 2 )

Gabbi P, Nogueira V, Haupental F, Rodrigues FS, do Nascimento PS, Barbosa S, Arend J, Furian AF, Oliveira MS, Dos Santos ARS, Royes LFF, Fighera MR (2018) Ammonia role in glial dysfunction in methylmalonic academia

The sample must be processed within 15 min of draw and analysed immediately

Increasingly, treatment algorithms are being developed using a multidisciplinary approach, although thus far, none have been proven clinically [517]