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PWE co-treatment generally diminished these increases towards control levels, suggesting normalization of androgen-driven structural and metabolic remodeling

Weight drops steadily, typically averaging two to four pounds weekly during aggressive caloric deficits or one to two pounds weekly with more moderate approaches

Retatrutide produces approximately 30-50% more frequent GI side effects than tirzepatide at comparable efficacy doses

The most commonly reported side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

Therefore, while the sperm count may drop to zero, the overall experience of ejaculation remains largely unchanged, allowing men to maintain their sexual health and enjoyment