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doi: 10.1016/S0140-6736(09)60432-3

Isatuximab causes preferential depletion of Tregs by causing apoptosis, inhibiting cell proliferation, and relieving conventional T cells from suppression, thereby inducing immunomodulation in MM patients (Figure 4) [80, 81]

Tesamorelin is a synthetic GHRH analog specifically studied and FDAapproved for reducing excess abdominal fat in HIV-associated lipodystrophy, with strong data on visceral fat reduction