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Enhancing mitochondrial function is the wellspring of efforts to optimize physical fitness and longevity at the cellular level

However, realistic expectations remain essential for long-term satisfaction

Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)