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Extraintestinal ADs have been linked to gut barrier dysfunction, with increased mucosal permeability displayed by individuals suffering from inflammatory rheumatic diseases such as rheumatoid arthritis (RA) (Mielants et al

Norris JM, Barriga K, Klingensmith G et al (2003) Timing of initial cereal exposure in infancy and risk of islet autoimmunity

Beyond carboxylation, vitamin K2 also influences cellular functions by modulating gene expression and inflammatory pathways, notably through inhibition of nuclear factor-B (NF-B) signaling ( 2 Vitamin K, osteoporosis, and bone health Osteoporosis is a non-communicable bone disease that affects 200 million people worldwide ( Vitamin K has been shown to have a pivotal role in bone health

doi: 10.3389/fimmu.2022.880201 2 ChaiKRuixuanZHUFujianLUOYaqianSHIMinghuiLIUYangfanXIAOet al