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TABLE 3 Jadad scale for randomised controlled trials

Gariani and Wang also showed that NR has benefits including enhanced FAO, mitochondrial biogenesis, and NAD +/SIRT1/PGC-1 signaling (Wang et al

Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML (2019) Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin

NR = not reached At the protocol specified final OS analysis, the median in the pemetrexed in combination with pembrolizumab and platinum chemotherapy arm was 22.0 months (95% CI: 19.5, 24.5) compared to 10.6 months (95% CI: 8.7, 13.6) in the placebo with pemetrexed and platinum chemotherapy arm, with an HR of 0.56 (95% CI: 0.46, 0.69)

W.CaoM.SinghP.et al