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Risk assessments for human inhalation toxicity based on traditional animal studies generally include a safety factor of 25 to account for uncertainties related to interspecies (animal-to-human: 2.5-safety factor) and inter-individual (human-to-human: 10-safety factor) variabilities ( in vitro PoDs from MucilAir readouts (i.e., TEER, lactate dehydrogenase leakage and resazurin metabolism analyses) with dosimetry information obtained from a computational fluid-particle dynamics (CFPD) model ( in vitro model was derived from human lung biopsies, the readouts measure MIEs for the mode of action (direct acting contact irritation) and the exposure modelling is sufficiently realistic and accurate

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It has been proposed that sepsis may also accelerate pre-existing cardiovascular dysfunction/disease [125]

Free Radic Res 2013