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In fact, this method has little effect on preventing the reformation of the IGF-1/IGFBP complex with the smaller IGFBPs (IGFBP-1 and IGFBP-4)

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This is suggestive of a prolonged formation of catechin via gut microbial degradation of procyanidins in the colon (Figure 3)

The present study hence focused on compounds, already in clinical use, with the potential to activate the Nrf2 stress response pathway