gst binds to gsh and glutathione Glutathione-Related Enzymes Proteins: A Review gsh glutathione s transferase Overexpression

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Fan L, Liu B, Wang Y, et al

These active components help reduce abnormal -syn aggregation, block its neurotoxic effects, inhibit the apoptosis of dopaminergic neurons in the substantia nigra, regulate microglial activation, reduce the release of pro-inflammatory factors such as TNF- and IL-1, enhance antioxidant defense systems (e.g., by upregulating the Nrf2/HO-1 pathway) to mitigate oxidative stress damage, and promote neuroregeneration and synaptic repair

doi: 10.1038/s41580-018-0074-2 256 ZengDHeSMaCWenYSongWXuQet al

Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase