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Oxidative stress, marked by an imbalance between free radicals and antioxidants, is implicated in IBD pathogenesis

This indicates a necessity for the development of therapeutics to inhibit the process

This is illustrated by the actions of a curcumin derivative, Curcumin5-8, which activates AMPK and regulates autophagy to ameliorate fatty liver, and the small-molecule inhibitor EW-7197, which blocks the TGF- receptor I to mitigate fibrosis and oxidative stress via the SMAD2/3 pathway

It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM

S., Conti, M., Wess, J., El-Armouche, A., Hasenfu, G., & Nikolaev, V