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Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models

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GHK-Cu: collagen and structure GHK-Cu is a copper-binding tripeptide associated with regulation across more than 4,000 genes, including collagen synthesis, antioxidant defense, wound healing, inflammation, and tissue breakdown. Circulating levels decline with age, from roughly 200 ng/mL at age 20 to about 80 ng/mL by 60. It clears damaged matrix while helping new collagen form and cross-link into stronger structure (matrix remodeling and lysyl oxidase activation). BPC-157: blood supply BPC-157 is a 15-amino-acid fragment from gastric juice

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