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Thus, we can assume that pathways additional to those involved in angiogenesis (Vukojevic et al., 2018) are associated with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017)

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Higher concentration supports smaller injection volumes during research dosing

A meta-analysis of six phase III RCTs ( 10.3389/fonc.2021.739263 ) found no significant increase in all-grade or high-grade hypertension with ICI+ VEGFi combinations compared with VEGFi monotherapy

However, we tried several values of V mean and V eff as well as replacing the ohmic formalism by the GHK formalism and every version of the model gave a qualitative synergy