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With respect to the Wnt inhibitors WIF1 and DKK1 , proflavine markedly increased WIF1 expression by 7.7-fold, the highest among all tested drugs

BIBLIOGRAPHY (1) Kumari M, Badrick E, Chandola T, Adam EK, Stafford M, Marmot MG, Kirschbaum C, Kivimaki M

Mechanistically, DOX stabilizes the copper importer SLC31A1 (CTR1) by inhibiting its proteasomal degradation and downregulating the copper efflux transporter ATPase Copper Transporting Beta (ATP7B), leading to a net increase in cellular copper [17, 76]

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