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Knockdown of SIRT6 inhibits melatonin-induced activation of the AMPK-PGC-1-AKT pathway, diminishing its cardioprotective effects [114]

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Glutathione, a potent endogenous antioxidant compound, is a likely mediator of these effects

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Introduction Breast cancer is the most common malignant tumor and the second capital reason for cancer death among women worldwide (1, 2)