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Retatrutide also covers GLP-1 and GIP (the same receptors tirzepatide hits), so it overlaps

ChemBioChem 4(8):748753 Wischik CM, Edwards PC, Lai RY, Roth M, Harrington C (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

This suggests that microorganisms exchange B-vitamin or B-vitamin metabolites among each other, thus enabling the survival of organisms that do not synthesize some or any of these essential cofactors