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Literature reviews confirm CGA activity at the levels of Nrf2, NF-B, and MAPK, along with associated anti-inflammatory effects [14,110]

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PEM is also thought to be linked to insufficient ATP levels due to a lack of available adenosine, which delays the rapid replenishment of ATP stores post-exercise and may contribute to prolonged recovery times observed in these patients following physical exertion (Lengert and Drossel, 2015)

It is a strong anti-oxidant that is toxic to melanocytes hence by reducing these cells, it reduces melanin production

Furthermore, melatonin plays an important regulatory role in the ubiquitin-proteasome pathway, responsible for controlling protein degradation