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doi: 10.1210/jcem-70-1-207 32 MatustikMCFurlanettoRWMeyerWJ3rd.Chronobiologic considerations in human growth hormone therapy

Transfused red blood cells (RBC) are taken up and degraded by the reticuloendothelial system (RES) or tissue macrophages, leading to a high accumulation of intracellular iron and saturation of plasma transferrin