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In perimenopausal women, a decline in circulating E2 levels is associated with a 50-80% increase in ROS production, positioning E2 loss as a key driver of mitochondrial oxidative stress

Selenoproteins carry out the major nutritional roles of Se and have a range of effects from antioxidant, redox-active, anti-inflammatory, anti-ferroptosis, transport of Se, reduction of endoplasmic reticulum (ER) stress, to the production of active thyroid hormone (Reference Rayman3)

2-hydroxyestrone [2-OHE1], 2-hydroxyestradiol [2-OHE2]), 4-hydroxyestrone [4-OHE1], and 4-hydroxyestradiol [4-OHE2]), as well as E1-3-glucuronide and 2&4-hydroxyestrone-N-acetyl-cysteine (2&4-OHE1-NAcCys)

Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis