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Under the ROS stimulation, the thin-sophisticated moiety (-SH) of cysteine residues is oxidized to form reversible intramolecular disulfide bonds (R-S-S-R) and sulfinyl groups (R-SOH), or irreversible sulfinic acids (R-SO 2 H) and sulfonic acids (R-SO 3 H) ( As we mentioned earlier, GPX7 does not contain domains bound to GSH, so it cannot participate in redox reactions with GSH as a substrate like other GPX family members

The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer

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Ferritinophagy mediated by NCOA4 promotes ferritin degradation and iron release, thereby increasing free iron content and further inducing ferroptosis [97]

During neurodegenerative disorder glial cells release some factors to reestablish integrity and repair damaged cells