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Data availability The atomic coordinates and experimental data generated in this study have been deposited in the Protein Data Bank (www.pdb.org) under accession code: 8J2W, 8J2X, 8J2Y

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This selectivity represents a fundamental difference from not only full-length growth hormone but also growth hormone secretagogues and analogs like tesamorelin, which increase endogenous growth hormone and subsequently elevate IGF-1