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[9] Pseudofolliculitis barbae can further be divided into two types of ingrown hairs: transfollicular and extrafollicular

IAV infection activates NF-B binding and induces the expression of antioxidant genes, including manganese SOD and indoleamine 2,3-dioxygenase, in human airway epithelial cells 78,79

H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)

Free radicals also deplete glutathione levels, increasing free radical damage and creating oxidative stress

Moreover, compared to many synthetic drug delivery agents, using exosomes facilitates cellular uptake due to their specific surface proteins (218, 223)