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Abbreviations IBD: Inflammatory bowel disease CD: Crohns disease UC: Ulcerative colitis DSS: Dextran sulfate sodium ALI: Acute lung injury JAK: Janus kinase STAT3: Signal transducer and activator of transcription 3 NF-B: Nuclear factor kappa-b NLRP3: Nod-like receptor pyrin domain-containing 3 NEK7: Nima-related kinase 7 BRD4: Bromodomain-containing protein 4 Wnt: Wingless/integrated signaling pathway TGF-: Transforming growth factor-beta AXL: Axl receptor tyrosine kinase FZD8: Frizzled-8 PIKfyve: Phosphatidylinositol-3-phosphate 5-kinase TLR3: Toll-like receptor 3 TLR4: Toll-like receptor 4 AhR: Aryl hydrocarbon receptor Nrf2: Nuclear factor erythroid 2-related factor 2 AMPK: Amp-activated protein kinase PXR: Pregnane x receptor TNF-: Tumor necrosis factor-alpha IL-1: Interleukin-1 beta IL-6: Interleukin-6 IL-8: Interleukin-8 IL-12: Interleukin-12 IL-17A: Interleukin-17 A IL-23: Interleukin-23 IFN-: Interferon-gamma Th1: T helper 1 cells Th2: T helper 2 cells Th17: T helper 17 cells CD4 T cells: Cluster of differentiation 4 positive t cells ROS: Reactive oxygen species iNOS: Inducible nitric oxide synthase HMGB1: High mobility group box 1 MLKL: Mixed lineage kinase domain-like protein H3K122Ac: Histone h3 lysine 122 acetylation CBP: Creb-binding protein FOXO-1: Forkhead box o 1 COL3A1: Collagen type 3 alpha 1 chain ACTA2: Actin alpha 2 DARTS: Drug affinity responsive target stability IC: Half maximal inhibitory concentration SNX10: Sorting nexin 10 HSP90: Heat shock protein 90 MSU: Monosodium urate DALYs: Disability-adjusted life years HALE: Healthy life expectancy References Zurba Y, Gros B, Shehab M (2023) Exploring the pipeline of novel therapies for inflammatory bowel disease

The localized effects sustain collagen support even without systemic administration