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These cardiac repair studies established TB-500 as one of the most extensively characterised peptide research tools for studying cardiac regeneration biology and provided the foundational evidence for thymosin beta-4s role as an endogenous cardiac repair mediator and establishing that actin-sequestering peptides have biological significance beyond cytoskeletal regulation in the context of cardiac injury response

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Rotating shift work, which disrupts circadian rhythms, has also been associated with a 4% increased risk for ischemic stroke for every 5 years, with an increased risk of stroke in women with longer durations of shift work ( 15 years) (Brown et al., 2009)