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It is of concern that the efficacy of MSCs is greatly limited by the local inflammatory microenvironment following SCI

Re-examination of the experiment by the same laboratory indicated that overproduction in MIN6 and rat islets of GDH indeed promoted conversion of glutamate to -ketoglutarate, thereby increasing TCA cycle activity without increasing the level of glutamate [74]

Philadelphia: WB Saunders, 2002, pp 1715-1750

The xCT pathway plays an important role in antioxidant defense by transporting extracellular cystine into cells and converting cystine to cysteine for GSH biosynthesis and ROS detoxification [16,46-48]

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