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Archived from the original on 2021-12-13

Insulin/IGF1 signaling regulates the mitochondrial biogenesis markers in steroidogenic cells of prepubertal testis, but not ovary

Despite clear advantages over classical LRAs, including a demonstrated ability to potently upregulate multiply-spliced HIV RNA and protein production, and an HIV-specific mechanism of action, several challenges remain in the translation of HIV Tat into a clinically applicable LRA

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Due to their high rate constant and high abundance, Prx are thought to be responsible for scavenging nanomolar concentrations of H 2 O 2 associated with redox signaling, while Gpx are likely important at higher intracellular concentrations, buffering high ROS levels to avoid cell damage and stress signaling response (Sena and Chandel, 2012)