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reported that catechin, a promising antioxidant, abundantly found in green tea, effectively reduces oxidative stress and alleviate ox-LDL-induced VMSC ferroptosis through activation of the Nrf2/solute carrier family 7 member 11 (SLC7A11)/GPX4 signaling axis, indicating its positive function in preventing atherosclerosis [96]

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One exception is RO7126209, deriving from the fusion between an AAA that failed in clinical trials (Lozupone et al., 2020), and an antibody (Ab) against transferrin receptor (Niewoehner et al., 2014), which mediated the BBB transport (Pardridge, 2020)