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Now we know that the substance responsible for beneficial qualities of shark fat is squalane

Collectively, these data suggest ndufs2 -/- zebrafish have enlarged livers with increased yolk lipid accumulation due in part to impaired FAO flux, owing to their upregulated NADH:NAD + ratio that is caused by their genetically-disrupted CI (NADH dehydrogenase) capacity and was likely exacerbated by disrupted one-carbon metabolism in the liver, as in mouse liver NAD(P)H is derived from serine catabolism (4, 34, 64)

doi:10.1164/ajrccm.158.5.9712069 Raff H, Ettema S, Eastwood D, Woodson B

Potsdam, DE

Zidovudine plates in concentration 400 g/ml were prepared for counter selection of the gene deletions