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How these cells genetically orchestrate this metabolic reprogramming is not known

RSL3, a compound containing an electrophilic moiety and a chloroacetamide moiety, could reacted with the nucleophilic amino acid residue at the active site of GPX4

FEBS J 2016;283:264052 [DOI] [PubMed] [Google Scholar] 61.Nagy G, Kardon T, Wunderlich L, Szarka A, Kiss A, Schaff Z, Banhegyi G, Mandl J.Acetaminophen induces ER dependent signaling in mouse liver