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however, this represents early-phase evidence only, and the mechanistic effects observed in trials including increased energy expenditure and lipolysis via glucagon receptor agonism have not yet been fully characterised in long-term human studies

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Longer-term Concerns Estrogen has protective effects on many body systems, so we need to consider some longer-term concerns in post-menopausal women, including: Higher risk of osteoporosis, cardiovascular and metabolic diseases, and vulvo-vaginal health and sexual well-being