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Therefore, this article provides a review of the mechanism of Nrf2 in RA and summarizes natural products that target Nrf2 and its associated pathways in the treatment of RA, aiming to offer new insights and strategies for the prevention and management of RA

It is often referred to as the "master antioxidant" due to its potent antioxidant properties

Metabolic flexibility Although glutamine is the primary carbon source for the TCA cycle in some cancer cells, replenishment of TCA cycle intermediates using alternative anaplerotic substrates reduces bioenergetic stress, thereby enabling resistance to inhibition of glutamine metabolism

6 Collectively, these functional changes are consistent with neutrophil polarization toward the N1 proinflammatory phenotype, 7 underscoring the propensity of neutrophils to undergo such polarization within the BM microenvironment remodeled by chronic inflammation