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The increased dependence on glutaminase metabolism is associated with mutations in BRAF in melanoma cells [109]

By contrast, highly selective reversible inhibitors, such as KDS2010 (~12,500-fold selectivity for MAO-B over MAO-A), demonstrated superior efficacy in mitigating aberrant astrocytic GABA release and oxidative stress without inducing compensatory pathways 543

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The substitution of glycine with alanine at the 15th position is theorized to enhance the peptides bioactivity