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2025;106 doi: 10.1016/j.arr.2025.102685

Pathway activity profiling (papi): from the metabolite profile to the metabolic pathway activity

A recurring mechanistic pattern involves iron accumulation, ferritinophagy activation, oxidative stress amplification and impairment of osteoblast or osteocyte viability

Another study indicated increased oxidative stress in brain tissue in STZ-induced type 1 diabetes (Bathina and Das 2021), and in another study, researchers reported that MDA levels, which are oxidative stress markers, increased and GSH levels decreased in the brain tissues of STZ-induced type 1 diabetic rats (Aydn et al