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Similarly, BioNTechs mRNA-based BNT153 and BNT152, encoding IL-2 and IL-7, respectively, are in a Phase I trial (NCT04710043) for advanced solid tumors (200)

Understanding what separates effective products from marketing gimmicks requires examining actual ingredients and concentrations

SPINDOC (SPIN1 docking protein) and KIF18B (Kinesin family member 18B) have also been shown to be overexpressed in HCC and can similarly play a role in promoting the proliferative, invasive, and metastatic capacities of HCC cells through activation of this pathway (132, 133)

Biochim Biophys Acta 78:594605

In contrast, increased percentage of infiltrating CD8 + T cells, CD4 + T cells, EpCAM+ macrophages and B cells were observed in the combination group, but not with either monotherapy (Fig