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Disclosures: Jun Li: Nothing to Disclose, Heng Yao: Nothing to Disclose, Hui Yang: Nothing to Disclose, Suwan Sun: Nothing to Disclose, Xi Liang: Nothing to Disclose, Jing Jiang: Nothing to Disclose, Jiaojiao Xin: Nothing to Disclose, Dongyan Shi: Nothing to Disclose, Xin Chen: Nothing to Disclose 2564 DEVELOPING A MACHINE LEARNING UNIVERSAL PREDICTOR FOR LIVER FIBROSIS PROGRESSION Kirstin Peters 1 Nicholas Valle 1 Jamie Yang 2 Michelle Guan 1 Tien Dong 1 , 1 UCLA, 2 University of California, Los Angeles Background: In the United States, liver disease and transplant rates are escalating despite advancements in managing viral hepatitis, largely driven by alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD), which accounted for 75% of transplants in 2022

[DOI] [PubMed] [Google Scholar] 74.Kelly LK, Porta NF, Goodman DM, Carroll CL, Steinhorn RH

Allometric scaling projected a long half-life of 16.1 hours with an efficacious once-daily dose of 200 mg in humans, consistent with the half-life reported in clinical studies

The calculated solvation energies of NAP and its metabolites, DNAP, NAP-AGLU, NAP-GLY, NAP-SU and DNAP-AGLU from PM3 calculations in kcal mol -1 are, respectively -12.26, -15.10, -17.93, -52.42 and -55.79 and their dipole moments from DFT calculations are 6.4, 6.0, 4.6, 7.1 and 6.9, respectively

They may also become more prone to insulin resistance, which represents a step toward diabetes