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an impure compound means you're not administering the intended amount of active substance

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Ultimately, this review aims to deepen the understanding of epigenetics-oriented therapeutic strategies and their further application in clinical settings

10.2337/db23-0430 Summary Keywords mitochondrial-driven diseases, preclinical models, cybrid, conplastic mouse, mitochondrial-nuclear eXchange (MNX) mice, mitochondrial replacement therapy (MRT), CRISPR/Cas9, organoid Citation Miller DM, Archer SL and Dunham-Snary KJ (2025) Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies

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