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Although the auto-amplifying mechanism between inflammation and cell death in MS pathology is generally recognized, no cell death-targeting therapies have made it to the clinic yet

Although the antioxidant capacity of flavonoids may be compromised after reacting with ROS, recent studies have shown that the oxidized derivatives of certain flavonoids can significantly enhance their original antioxidant properties by activating the NRF2/KEAP1 pathway and upregulating the cell's endogenous antioxidant capacity [423]

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Fehm, Sniffing neuropeptides: a transnasal approach to the human brain, Nature Neuroscience, vol