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Description

BMJ 2006;332:584-8

Class I ferroptosis inducers (FINs), including sorafenib, sulfasalazine, erastin, and its analog imidazole ketone erastin, inhibit system Xc-, disturb the synthesis of GSH, and subsequently deplete GSH to suppress the GPX4 enzyme activity

Selective advantage may be the result both of drug resistance and of other cell traits: acceleration of the proliferation rate, alterations of cell sensitivity to growth factors, etc