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The gathering of abemaciclib and IRR (10 Gy) significantly increased the protein concentration of BAX and P53 and decreased Bcl-2, CK18, COX2, IL-6, and IL-1 concentrations in MCF-7 and MDA-MB-231 cell lines emulated to abemaciclib alone

Acknowledgements The authors thank all researchers who contributed to the advancement of science

In a similar way, acrolein appears to stimulate oxidative stress damage, producing high levels of ceramide, which is accountable for the incrementation of cytosolic Ca 2+ concentration and, consequently, the eryptosis levels [254]

10.1016/j.tips.2017.02.005 9 AudiaJ