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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

This element has known effects on diabetes and cardiovascular disorders through its impact on inflammatory reactions (140)

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Without a loading dose, it would take months to achieve a therapeutic effect, which is likely clinically unacceptable

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