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The autophagylysosome pathway is not simple or unidirectional

[DOI] [Google Scholar] 137.Song W., Wei F., Gao S., Dong C., Hao J., Jin L., Li F., Wei P., Guo J., Wang R

Obesity increases adipocyte development and cell hypoxia, which stimulates inflammatory chemokines and cytokines via HIF1 in adipose tissue macrophages (ATMs), inducing their polarization into the M1 phenotype (Shi et al., 2006)

Souilem F, Fernandes , Calhelha RC, Barreira JCM, Barros L, Skhiri F, Martins A, Ferreira ICFR (2017) Wild mushrooms and their mycelia as sources of bioactive compounds: antioxidant, anti-inflammatory and cytotoxic properties

Each tier tells a distinct story about efficacy, tolerability, and the tradeoffs researchers face when selecting a protocol