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Targeting VEGF-independent cords A number of different mechanisms, including the upregulation of other angiogenic pathways such as the Notch pathway, have been described to play a role in the development of tumor vessels that are insensitive to anti-VEGF therapy [4, 14, 15, 34]

The authors would like to thank Alar Mirka, Richard Rosenbaum, Shaban Demirel, Amy Reiter, and Kathy Dodson from Legacy Health Systems for their roles in running the clinical trial

Depression patients generally exhibit reduced vagal tone and decreased heart rate variability (HRV), suggesting parasympathetic insufficiency

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