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The clinical study showed that K18 and HMGB1 are translational blood protein markers of necrosis and immune response in acetaminophen overdose patients (Antoine et al

Additionally, induced ERCs have been shown to differentiate into functional hepatocyte-like cells ( 3.1.4 Expanded therapeutic potential of MenSCs through multilineage differentiation Multilineage-differentiating stress-enduring (Muse) cells, derived from mesenchymal stem cells (MSCs), are pluripotent cells with the capacity to differentiate into all three germ layers and exhibit enhanced resistance to environmental stress (Li et al., 2013a), and preferentially home to sites of tissue injury (Kushida et al., 2018), thereby overcoming the limitations associated with conventional MSCs in clinical applications

The incorporation of rotigotine into an extended-release microspheres (LY03003) was designed to overcome limitations associated with the existing rotigotine formulation, Neupro, a daily transdermal patch

This understanding will be crucial in identifying and defining critical therapeutic targets, ultimately paving the way for more targeted and effective treatments