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Abstract Major depressive disorder (MDD) is severely disabling, and current treatments have limited efficacy

A COVID-19 patient presented with only mild respiratory symptoms but with encephalitis (60), and responded to steroid therapy, suggesting the neurological symptoms could have involved a cytokine-mediated hyperinflammatory response

In addition to clinical trials, some TCMs, such as Rhodiola rosea , 393 Hippophae rhamnoides , 394 Aesculus chinensis , 395 Portulaca oleracea Linn ( Portulacaceae ), 396 Phlomis younghusbandii Mukerj ( Lamiaceae ), 397 Pueraria lobata , 398 Eleutheroside B , 399 and Notoginsenoside R1 , 400,401 showed promise in preventing HAPE/HACE in rat models by inhibiting the infiltration of inflammatory cells, the production of inflammatory cytokines, and apoptosis/pyroptosis

The benefits of the injections can be sustained by taking the tablets regularly