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Increased GFAP and vimentin have been linked to altered cell cycle and reduced cell proliferation and neurogenesis processes in senescence (Larsson et al., 2004)

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Furthermore, glycogen degeneration of distal tubules, fatty degeneration of glomerular endothelium and hypertrophy of glomeruli and mesangium were observed in the kidneys of the diabetic animals when histopathological evaluation was performed at 4, 8, and 15 weeks (glomerular and mesangial hypertrophy were observed only at 15 weeks)